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Northwestern University Feinberg School of Medicine
Mesulam Center for Cognitive Neurology and Alzheimer’s Disease

Publications

  1. Jutten RJ, Ho EH, Karpouzian-Rogers T, van Hulle C, Carlsson C, Dodge HH, Nowinski CJ, Gershon R, Weintraub S, Rentz DM  Computerized cognitive testing to capture cognitive decline in Alzheimer's disease: Longitudinal findings from the ARMADA study.  Alzheimers Dement (Amst)  2025;17(1):e70046. pii:e70046
  2. Fernandopulle MS, Cotty-Fattal Z, Smith H, Mejia Bautista M, Ahrendsen JT, Jennings LJ, Santana-Santos L, Sukhanova M, Conway K, Primdahl D  et al.  Dual TERT promoter mutations in an oligodendroglioma, IDH-mutant, 1p/19q co-deleted.  J Neuropathol Exp Neurol  2025 Jan 11;. pii:nlae138
  3. Duckett D, Vormittag-Nocito ER, Jamshidi P, Sukhanova M, Parker S, Brat DJ, Jennings LJ, Santana-Santos L  Accurate identification of primary site in tumors of unknown origin (TUO) using DNA methylation.  NPJ Precis Oncol  2025 Jan 10;9(1):8. pii:8
  4. Smith H, Jean J, Duckett D, Vormittag-Nocito E, Nezami BG, Jennings LJ, Ahrendsen JT, Yang XJ, Primdahl D, Conway K  et al.  Diagnostic utility of multimodal advanced molecular testing to classify metastases of unknown primaries: A case of a patient with no known medical history.  J Neuropathol Exp Neurol  2025 Jan 01;84(1):84-86. doi:10.1093/jnen/nlae086
  5. Shaughnessy LW, Weintraub S  The role of neuropsychological assessment in the evaluation of patients with cognitive-behavioral change due to suspected Alzheimer's disease and other causes of cognitive impairment and dementia.  Alzheimers Dement  2024 Dec 28;. doi:10.1002/alz.14363
  6. Vargas-Gonzalez JC, Dimal N, Cortez K, Heuer H, Forsberg LK, Appleby BS, Barmada S, Bozoki A, Clark D, Cobigo Y  et al.  Psychotropic medication usage in sporadic versus genetic behavioral-variant frontotemporal dementia.  Alzheimers Dement  2024 Dec 23;. doi:10.1002/alz.14448
  7. Hammers DB, Eloyan A, Taurone A, Thangarajah M, Gao S, Beckett L, Polsinelli AJ, Kirby K, Dage JL, Nudelman K  et al.  Longitudinal cognitive performance of participants with sporadic early onset Alzheimer's disease from LEADS.  Alzheimers Dement  2024 Dec 23;. doi:10.1002/alz.14439
  8. Hammers DB, Eloyan A, Thangarajah M, Taurone A, Beckett L, Gao S, Polsinelli AJ, Kirby K, Dage JL, Nudelman K  et al.  Differences in baseline cognitive performance between participants with early-onset and late-onset Alzheimer's disease: Comparison of LEADS and ADNI.  Alzheimers Dement  2024 Dec 23;. doi:10.1002/alz.14218
  9. Ho EH, Ece B, Novack MA, Pila S, Karpouzian-Rogers T, Mather MA, Dworak EM, Hosseinian Z, Bucko P, Kaat AJ  et al.  Protocol for a multi-domain scoping review to identify measures of decision-making ability in an ageing population.  BMJ Open  2024 Dec 22;14(12):e084178. pii:e084178
  10. Rose S, Gergoire A, Pal S, Reader J, Bhaumik A, Slotkin J, Ho E, Nowinski CJ, Persad CC, Maher AC  et al.  Evaluating the factor structure and construct validity of the NIH toolbox in older adults, with a focus on cognitive normalcy and amnestic mild cognitive impairment: considerations for diversity, including insights from persons over 85 years of age and Black older Americans.  J Int Neuropsychol Soc  2024 Dec 16;:1-6. doi:10.1017/S1355617724000699
  11. Shi J, Touchon J, Middleton LT, Rovira MB, Vassar R, Vellas B, Shen Y  Now and future: Strategies for diagnosis, prevention and therapies for Alzheimer's disease.  Sci Bull (Beijing)  2024 Dec 15;69(23):3777-3784. doi:10.1016/j.scib.2024.09.042
  12. Le Borgne J, Gomez L, Heikkinen S, Amin N, Ahmad S, Choi SH, Bis J, Grenier-Boley B, Rodriguez OG, Kleineidam L  et al.  X-chromosome-wide association study for Alzheimer's disease.  Mol Psychiatry  2024 Dec 04;. doi:10.1038/s41380-024-02838-5
  13. Nuytemans K, Franzen S, Broce IJ, Caramelli P, Ellajosyula R, Finger E, Gupta V, Gupta V, Illán-Gala I, Loi SM  et al.  Gaps in biomedical research in frontotemporal dementia: A call for diversity and disparities focused research.  Alzheimers Dement  2024 Dec;20(12):9014-9036. doi:10.1002/alz.14312
  14. Haynes G, Muhammad F, Weber KA, Khan AF, Hameed S, Shakir H, Van Hal M, Dickson D, Rohan M, Dhaher Y  et al.  Tract-specific magnetization transfer ratio provides insights into the severity of degenerative cervical myelopathy.  Spinal Cord  2024 Dec;62(12):700-707. doi:10.1038/s41393-024-01036-y
  15. Kostelecky N, Wadhwani N, Golubovich I, Vormittag-Nocito E, Gao J, Jennings L, Caron M, Jamshidi P, Ahrendsen JT, Castellani R  et al.  Transdifferentiation of metastatic melanoma into cerebellar angiosarcoma.  J Neuropathol Exp Neurol  2024 Dec 01;83(12):1081-1083. doi:10.1093/jnen/nlae075
  16. Castellani RJ  Biomarker-only diagnosis of Alzheimer's disease: Not ready for prime time.  J Alzheimers Dis  2024 Nov 29;:13872877241301805. doi:10.1177/13872877241301805
  17. Hopkins T, Kwon E, Lapins A, Gill N, Roberts A, Rogalski E  Assessment of disease impact through health-related quality of life measurement in primary progressive aphasia.  Alzheimers Dement (N Y)  2024;10(4):e12499. pii:e12499
  18. Rogalski E, Bona M, Esparza M, Mooney A, Fried-Oken M, Rademaker A, Roberts A  Communication Bridge-2 randomized controlled trial: Recruitment and baseline features.  Alzheimers Dement  2024 Nov 26;. doi:10.1002/alz.14168
  19. Wirtshafter HS, Solla SA, Disterhoft JF  A universal hippocampal memory code across animals and environments.  bioRxiv  2024 Nov 19;. pii:2024.10.24.620127
  20. Volkmer A, Alves EV, Bar-Zeev H, Barbieri E, Battista P, Beales A, Beber BC, Brotherhood E, Cadorio IR, Carthery-Goulart MT  et al.  An international core outcome set for primary progressive aphasia (COS-PPA): Consensus-based recommendations for communication interventions across research and clinical settings.  Alzheimers Dement  2024 Nov 13;. doi:10.1002/alz.14362
  21. Castellani RJ, Jamshidi P, Plascencia-Villa G, Perry G  The Amyloid Cascade Hypothesis: A Conclusion in Search of Support.  Am J Pathol  2024 Nov 10;. pii:S0002-9440(24)00407-3
  22. Jeon S, Salvo MA, Alia AO, Popovic J, Zagardo M, Chandra S, Nassan M, Gate D, Vassar R, Cuddy LK  Neuronal ACE1 knockout disrupts the hippocampal renin angiotensin system leading to memory impairment and vascular loss in normal aging.  Neurobiol Dis  2024 Nov;202:106729. doi:10.1016/j.nbd.2024.106729
  23. Rao NR, DeGulis O, Nomura T, Lee S, Hark TJ, Dynes JC, Dexter EX, Dulewicz M, Ge J, Upadhyay A  et al.  Levetiracetam prevents Aβ42 production through SV2a-dependent modulation of App processing in Alzheimer's disease models.  bioRxiv  2024 Oct 28;. pii:2024.10.28.620698
  24. Vandebergh M, Ramos EM, Corriveau-Lecavalier N, Ramanan VK, Kornak J, Mester C, Kolander T, Brushaber DE, Staffaroni AM, Geschwind DH  et al.  Gene-Specific Effects on Brain Volume and Cognition of TMEM106B in Frontotemporal Lobar Degeneration.  Neurology  2024 Oct 22;103(8):e209832. pii:e209832
  25. Russo ML, Ayala G, Neal D, Rogalsky AE, Ahmad S, Musial TF, Pearlman M, Bean LA, Farooqi AK, Ahmed A  et al.  Alzheimer's-linked axonal changes accompany elevated antidromic action potential failure rate in aged mice.  Brain Res  2024 Oct 15;1841:149083. doi:10.1016/j.brainres.2024.149083
  26. Chandra S, Vassar RJ  Gut microbiome-derived metabolites in Alzheimer's disease: Regulation of immunity and potential for therapeutics.  Immunol Rev  2024 Oct;327(1):33-42. doi:10.1111/imr.13412
  27. Arseni D, Nonaka T, Jacobsen MH, Murzin AG, Cracco L, Peak-Chew SY, Garringer HJ, Kawakami I, Suzuki H, Onaya M  et al.  Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP type C.  Nature  2024 Oct;634(8034):662-668. doi:10.1038/s41586-024-08024-5
  28. Chandra S, Vassar R  The role of the gut microbiome in the regulation of astrocytes in Alzheimer's disease.  Neurotherapeutics  2024 Oct;21(6):e00425. pii:e00425
  29. O'Conor R, Russell AM, Pack A, Oladejo D, Filec S, Rogalski E, Morhardt D, Lindquist LA, Wolf MS  Managing medications among individuals with mild cognitive impairment and dementia: Patient-caregiver perspectives.  J Am Geriatr Soc  2024 Oct;72(10):3011-3021. doi:10.1111/jgs.19065
  30. Castellani RJ, Jamshidi P  Cerebral amyloid-β-related angiitis and iatrogenic cerebral amyloid angiopathy-related vasculitis: Implications for amyloid-related imaging abnormalities.  J Neuropathol Exp Neurol  2024 Oct 01;83(10):890-892. doi:10.1093/jnen/nlae068
  31. Sridharan PS, Koh Y, Miller E, Hu D, Chakraborty S, Tripathi SJ, Kee TR, Chaubey K, Vázquez-Rosa E, Barker S  et al.  Acutely blocking excessive mitochondrial fission prevents chronic neurodegeneration after traumatic brain injury.  Cell Rep Med  2024 Sep 17;5(9):101715. pii:101715
  32. Fortington LV, Cassidy JD, Castellani RJ, Gardner AJ, McIntosh AS, Austen M, Kerr ZY, Quarrie KL  Epidemiological Principles in Claims of Causality: An Enquiry into Repetitive Head Impacts (RHI) and Chronic Traumatic Encephalopathy (CTE).  Sports Med  2024 Sep 15;. doi:10.1007/s40279-024-02102-4
  33. Sasmita AO, Depp C, Nazarenko T, Sun T, Siems SB, Ong EC, Nkeh YB, Böhler C, Yu X, Bues B  et al.  Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer's disease model mice.  Nat Neurosci  2024 Sep;27(9):1668-1674. doi:10.1038/s41593-024-01730-3
  34. Barbieri E, Salvo JJ, Anderson NL, Simon S, Ables-Torres L, Los MA, Behn J, Bonakdarpour B, Holubecki AM, Braga RM  et al.  Progressive verbal apraxia of reading.  Cortex  2024 Sep;178:223-234. doi:10.1016/j.cortex.2024.06.011
  35. Reznicek J, Sharifai N, Jamshidi P, Wadhwani N, Ahrendsen JT  Embryonal and pineal tumours.  Cytopathology  2024 Sep;35(5):561-571. doi:10.1111/cyt.13350
  36. Plascencia-Villa G, Castellani RJ, Perry G  Central role of brain regulatory T cells in the inflammatory cascade in Alzheimer's disease.  Proc Natl Acad Sci U S A  2024 Aug 06;121(32):e2412255121. pii:e2412255121
  37. Høilund-Carlsen PF, Alavi A, Barrio JR, Castellani RJ, Costa T, Herrup K, Kepp KP, Neve RL, Perry G, Revheim ME  et al.  Donanemab, another anti-Alzheimer's drug with risk and uncertain benefit.  Ageing Res Rev  2024 Aug;99:102348. doi:10.1016/j.arr.2024.102348
  38. Zhang M, Ho E, Nowinski CJ, Fox RS, Ayturk E, Karpouzian-Rogers T, Novack M, Dodge HH, Weintraub S, Gershon R  The Paradox in Positive and Negative Aspects of Emotional Functioning Among Older Adults with Early Stages of Cognitive Impairment.  J Aging Health  2024 Aug;36(7-8):471-483. doi:10.1177/08982643231199806
  39. Mather MA, Ho EH, Bedjeti K, Karpouzian-Rogers T, Rogalski EJ, Gershon R, Weintraub S  Measuring Multidimensional Aspects of Health in the Oldest Old Using the NIH Toolbox: Results From the ARMADA Study.  Arch Clin Neuropsychol  2024 Jul 24;39(5):535-546. doi:10.1093/arclin/acad105
  40. Rajani RM, Ellingford R, Hellmuth M, Harris SS, Taso OS, Graykowski D, Lam FKW, Arber C, Fertan E, Danial JSH  et al.  Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease.  PLoS Biol  2024 Jul;22(7):e3002727. pii:e3002727
  41. Chia R, Ray A, Shah Z, Ding J, Ruffo P, Fujita M, Menon V, Saez-Atienzar S, Reho P, Kaivola K  et al.  Genome sequence analyses identify novel risk loci for multiple system atrophy.  Neuron  2024 Jul 03;112(13):2142-2156.e5. doi:10.1016/j.neuron.2024.04.002
  42. Nassan M  Proposal for a Mechanistic Disease Conceptualization in Clinical Neurosciences: The Neural Network Components (NNC) Model.  Harv Rev Psychiatry  2024 Jul 01;32(4):150-159. doi:10.1097/HRP.0000000000000399
  43. Tyner CE, Boulton AJ, Slotkin J, Cohen ML, Weintraub S, Gershon RC, Tulsky DS  Exploring symptom clusters in mild cognitive impairment and dementia with the NIH Toolbox.  J Int Neuropsychol Soc  2024 Jul;30(6):603-614. doi:10.1017/S1355617724000055
  44. Cahan J, Finley JA, Cotton E, Orban ZS, Jimenez M, Weintraub S, Sorets T, Koralnik IJ  Cognitive functioning in patients with neuro-PASC: the role of fatigue, mood, and hospitalization status.  Front Neurol  2024;15:1401796. pii:1401796
  45. McCord M, Jamshidi P  Targeting the cell cycle to enhance chemotherapy efficacy in glioblastoma.  Neuro Oncol  2024 Jun 03;26(6):1097-1098. doi:10.1093/neuonc/noae062
  46. Valentino RR, Scotton WJ, Roemer SF, Lashley T, Heckman MG, Shoai M, Martinez-Carrasco A, Tamvaka N, Walton RL, Baker MC  et al.  MAPT H2 haplotype and risk of Pick's disease in the Pick's disease International Consortium: a genetic association study.  Lancet Neurol  2024 May;23(5):487-499. doi:10.1016/S1474-4422(24)00083-8
  47. Ayala I, Bahrami A, Pan Y, Spencer C, Flanagan ME, Mesulam MM, Gefen T, Geula C  Loss and microglia phagocytosis of synaptic proteins in frontotemporal lobar degeneration with TDP-43 proteinopathy.  Neurochem Int  2024 May;175:105719. doi:10.1016/j.neuint.2024.105719
  48. Vandebergh M, Ramos EM, Corriveau-Lecavalier N, Ramanan VK, Kornak J, Mester C, Kolander T, Brushaber D, Staffaroni AM, Geschwind D  et al.  Gene specific effects on brain volume and cognition of TMEM106B in frontotemporal lobar degeneration.  medRxiv  2024 Apr 05;. pii:2024.04.05.24305253
  49. Iverson GL, Gardner AJ, Castellani RJ, Kissinger-Knox A  Applying the Consensus Criteria for Traumatic Encephalopathy Syndrome Retrospectively to Case Studies of Boxers from the 20th Century.  Neurotrauma Rep  2024;5(1):337-347. doi:10.1089/neur.2023.0134
  50. Høilund-Carlsen PF, Alavi A, Castellani RJ, Neve RL, Perry G, Revheim ME, Barrio JR  Alzheimer's Amyloid Hypothesis and Antibody Therapy: Melting Glaciers?  Int J Mol Sci  2024 Mar 31;25(7). pii:3892

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