The Longitudinal Early-onsetAlzheimer's Disease Study (LEADS) is a non-randomized, natural history,non-treatment study designed to look at disease progression in individuals withearly onset Alzheimer's disease (EOAD). Clinical/cognitive, imaging, biomarker,and genetic characteristics will be assessed across two cohorts: (1)individuals with cognitive impairment and (2) cognitively normal controlparticipants. The primary objectives of the LEADS study are to: collectlongitudinal assessments and biomarker data; to compare baseline andlongitudinal cognitive and functional characteristics between cognitivelyimpaired and cognitively normal individuals, and EOAD and Late OnsetAlzheimer's Disease (LOAD) individuals from the Alzheimer's DiseaseNeuroimaging Initiative (ADNI); and to study the associations of longitudinalclinical and cognitive assessments with multimodal imaging and biofluid markersthat capture different elements of the AD pathophysiological cascade.
Meets NIA-AA criteria for MCI due to AD or probable AD dementia
Have capacity to provide informed consent (IC) or has a legally authorized representative or guardian who provides IC
Age between 40-64 years (inclusive) at the time of consent
Must have a study partner (informant) who spends a minimum average of 10 hours per week with the participant (e.g., family member, significant other, friend, caregiver) who is generally aware of the participant's cognitive and functional performance
Not pregnant or lactating. Women must be two years post-menopausal, be surgically sterile or have a negative pregnancy test prior to each PET scan
Fluent in English
Inclusion Criteria (Cognitively Normal Cohort Only):
Meets criteria for cognitively normal, based on an absence of significant impairment in cognitive functions or activities of daily living
Have capacity to provide informed consent
Age between 40-64 years (inclusive) at the time of consent
Must have a study partner (informant) who spends a minimum average of 10 hours per week with the participant (e.g., family member, significant other, friend, caregiver) who is generally aware of the participant's cognitive and functional performance
Not pregnant or lactating. Women must be two years post-menopausal, be surgically sterile, or have a negative pregnancy test prior to each PET scan