Searle Building Room 11-467
320 E Superior
Chicago IL 60611
Description of Interests
My research falls under the broad umbrella of aging and dementia and uses a multimodal approach to investigate two aging perspectives: primary progressive aphasia (PPA) in which neurodegenerative disease invades the language network and SuperAging in which individuals are seemingly resistant to the deleterious changes in memory associated with “normal” or more typical cognitive aging. My investigations have provided new fundamental knowledge with translational implications for cognitive aging, dementia, and neurodegenerative disease as well as the cognitive neuroscience of language and memory. Since joining the faculty at the Cognitive Neurology and Alzheimer’s disease Center (CNADC) at Northwestern University Feinberg School of Medicine in 2008, I have led the neuroimaging arm of our NIDCD funded Language in PPA R01 project and the cognitive and neuroimaging arm of the SuperAging study. While structural neuroimaging is my primary method of investigation it is not the only tool I use. My other investigations have explored the role of genetic, developmental and acquired factors in aging and dementia, which demonstrates my capacity to collect and integrate multidisciplinary data. I have a successful history of funding and recently received R01 funding from the NINDS to examine the relationship between clinical decline, brain atrophy and putative underlying pathology using PET amyloid imaging.
Aging; Alzheimer's Disease; Dementia; Frontotemporal Dementia; Neurology; Neuroscience; Primary Progressive Aphasia; Quantitative MRI
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